Compositions de vecteur a base de virus utiles pour la transduction de cellules eucaryotes

Virus-based vector compositions useful for transducing eukaryotic cells

Abstract

The present invention provides viral vector compositions of high titer and purity, as well as methods for production of said compositions. The methods of the invention incorporate multiple features, such as production of viral vector particles in serum free media and multiple harvesting steps following transduction of the producer cell which provides for enhanced production of said viral vectors. The viral vector compositions of the invention, by virtue of their high titer and purity, minimize the deleterious phenotypic changes that typically occur following transduction of target cells, such as loss of a sub-population of transduced cells, and effects on proliferation, differentiation, reprogramming or functionality of transduced cells.

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