Nouveau derive indazole substitue en position 1

Novel 1-substituted indazole derivative

Abstract

Provided is a therapeutic drug for diseases associated with central nervous system (CNS) and/or peripheral nervous system (PNS) cholinergicity, diseases associated with smooth muscle contraction, endocrine diseases, diseases associated with neurodegeneration, and the like, said therapeutic drug having strong a7 nicotinic acetylcholine receptor (a7 nAChR)-regulating activity and that contains a compound represented by formula (I) or a pharmaceutically acceptable salt thereof. [In formula (I), A is CR1E or a nitrogen atom, X-Y-Z is N-CO-NR3AR3B, or the like, R1A through R1E are the same or different and represent hydrogen atoms, or the like, R2A through R2D are the same or different and represent hydrogen atoms, or the like, R3A and R3B are the same or different and represent optionally substituted C3-10 cycloalkyls, or the like, and n is 1 or 2.]

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